Op dinsdag 24 januari 2023 promoveert Gerben Lassche MSc aan de Radboud Universiteit Nijmegen op het proefschrift
Translation of salivary gland cancer tumor biology to the clinic.

De promotie vindt plaats om 16.30 uur.

Promotoren: prof. dr. C.M.L. van Herpen
prof. dr. J.A. Schalken

Co-promotor: dr. G.W.C.T. Verhaegh

Salivary gland cancer is a rare form of cancer. In total, 22 different subtypes of salivary gland cancer can be distinguished, and each subtype behaves differently. The rarity and different behavior of these tumors hinders adequate treatment of patients with recurrent or metastatic disease. This thesis aimed to unravel the tumor biology, such as tumor growth, mechanisms of metastasis and genetic changes, in the three main subtypes of salivary gland cancer, to eventually improve treatment. The research described in my thesis has shown that DNA changes that are suitable for targeted therapy can be found in approximately half of all patients. Based on these findings, new treatment recommendations have been made. In addition, I describe a method for culturing three-dimensional salivary gland cancer tumor models, so-called organoids. Although these 3D models still have important shortcomings, it is expected that they could be used to test new treatments for patient with salivary gland cancer in near future.

Gerben Lassche obtained his Master’s degree in Medicine, cum laude, at the Radboud University. Thereafter he started working as physician-scientist at the department of medical oncology at the Radboudumc. Currently he is working as resident internal medicine at the Canisius Wilhelmina Hospital in Nijmegen.Proefschrift Gerben Lassche